Description
Product Characteristics: KARP1, KU80, KUB2, Ku86, NFIV, TLAA, Lupus Ku Autoantigen Protein P80, Nuclear factor IV, 86 kDa of Ku antigen, CTC box-binding factor 85 kDa, Thyroid-lupus autoantigen
Target Information: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]